The association of serum ferritin levels to risk for developing coronary heart disease
Kuczmarski MF, Olesnevich ME, Mason M, Fang C, Zonderman AB, Evans MK. The association of serum ferritin levels to risk for developing coronary heart disease. Paper presented at the 2011 Food and Nutrition Conference and Expo; 24-27 September 2011; San Diego, CA. 2011
Research Outcome - To determine the risk for developing coronary heart disease in adults using the Framingham Heart Study’s 10-yr risk algorithm for Coronary Heart Disease (CHD). Thereafter, to identify the impact of iron stores on coronary heart disease risk. Methods – The sample consists of socioeconomically diverse participants from the baseline Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. This population included African American and white men (n = 949) and women (n = 874), ages 30-64 years living in Baltimore, Maryland. Ordinal logistic regression modeling was used to interpret risk scores. Proportional odds modeling was used to analyze four predetermined divisions of ranked CHD risk (4-high; 3-increased; 2-slight; 1-minimal) for men and women separately. Results – Serum ferritin was not associated with C-reactive protein. For men, there was a 1.2% increase in 10-year CHD risk for every 10-unit rise in serum ferritin. Other significant predictors for men included, increased body mass index, white race, unemployment, and high sensitivity C-reactive protein >1, but not education. For women, serum ferritin, increased body mass index, lower educational level, post-menopausal status, and high sensitivity C-reactive protein >3 were all significant predictors of increased CHD risk. However, race and employment status were not significant risk predictors. Conclusions – Serum ferritin impacted CHD risk for men and women in the HANDLS study. Future research on heart attack incidence and mortality data from this longitudinal study will provide valuable insight into the role of iron mediated oxidative damage in the development of CHD.
Kuczmarski MF, Olesnevich ME, Mason M, Fang C, Zonderman AB, Evans MK. The association of serum ferritin levels to risk for developing coronary heart disease. Paper presented at the 2011 Food and Nutrition Conference and Expo; 24-27 September 2011; San Diego, CA. 2011
Research Outcome - To determine the risk for developing coronary heart disease in adults using the Framingham Heart Study’s 10-yr risk algorithm for Coronary Heart Disease (CHD). Thereafter, to identify the impact of iron stores on coronary heart disease risk. Methods – The sample consists of socioeconomically diverse participants from the baseline Healthy Aging in Neighborhoods of Diversity across the Life Span (HANDLS) study. This population included African American and white men (n = 949) and women (n = 874), ages 30-64 years living in Baltimore, Maryland. Ordinal logistic regression modeling was used to interpret risk scores. Proportional odds modeling was used to analyze four predetermined divisions of ranked CHD risk (4-high; 3-increased; 2-slight; 1-minimal) for men and women separately. Results – Serum ferritin was not associated with C-reactive protein. For men, there was a 1.2% increase in 10-year CHD risk for every 10-unit rise in serum ferritin. Other significant predictors for men included, increased body mass index, white race, unemployment, and high sensitivity C-reactive protein >1, but not education. For women, serum ferritin, increased body mass index, lower educational level, post-menopausal status, and high sensitivity C-reactive protein >3 were all significant predictors of increased CHD risk. However, race and employment status were not significant risk predictors. Conclusions – Serum ferritin impacted CHD risk for men and women in the HANDLS study. Future research on heart attack incidence and mortality data from this longitudinal study will provide valuable insight into the role of iron mediated oxidative damage in the development of CHD.
