Fish consumption, N-3 fatty acid intakes and their association with depressive symptoms among US adults: HANDLS study
Beydoun MA, Beydoun HA, Fanelli Kuczmarski M, Hibbeln JR, Evans MK, Zonderman AB. Fish consumption, N-3 fatty acid intakes and their association with depressive symptoms among US adults: HANDLS study. Paper presented at the 43rd Annual Meeting of the Society for Epidemiologic Research; 23-26 June 2010. American Journal of Epidemiology. 2010;171(suppl):S72.
Evidence of an inverse association between depressive symptoms and n-3 fatty acids is growing though is still inconsistent among US adults. This was a population-based, cross-sectional study of 1,794 adults (30-65 years) in Baltimore city, Maryland (2004-2009). The 20-item Center for Epidemiologic Studies Depression Scale (CES-D) scale was used. Total fish consumption, n-3 highly unsaturated fatty acids (≥20C) (HUFA), n-3 polyunsaturated fatty acids (≥18 C)(PUFA), and plausible ratios (e.g. n-3 HUFAs:n-6 HUFAs) were estimated with two 24-hr dietary recalls. The prevalence of CES-D score ≥16 was 21.2% among men and 31.6% among women. In women, the uppermost tertile (T3) of fish consumption (compared to T1) was associated with reduced odds of CES-D score≥16 by 38%, with a significant effect modification by sex. The n-3 HUFA:n-6 PUFA ratio exhibited clear inverse dose-response relationship with elevated depressive symptoms among women [T2 vs. T1: OR = 0.68 (95% CI = 0.48, 0.98) and T3 vs. T1: OR = 0.59 (95% CI = 0.41, 0.86)]. For fish consumption, n-3 HUFA (% energy) and n-3 HUFA:n-6 PUFA ratio, a significant inverse relationship with the CES-D domain of somatic complaints and a direct relationship with positive affect was found only among women. In US women, increasing fish consumption, n-3 HUFA and the n-3 HUFA:n-6 PUFA ratio may decrease the risk of elevated depressive symptoms.
Beydoun MA, Beydoun HA, Fanelli Kuczmarski M, Hibbeln JR, Evans MK, Zonderman AB. Fish consumption, N-3 fatty acid intakes and their association with depressive symptoms among US adults: HANDLS study. Paper presented at the 43rd Annual Meeting of the Society for Epidemiologic Research; 23-26 June 2010. American Journal of Epidemiology. 2010;171(suppl):S72.
Evidence of an inverse association between depressive symptoms and n-3 fatty acids is growing though is still inconsistent among US adults. This was a population-based, cross-sectional study of 1,794 adults (30-65 years) in Baltimore city, Maryland (2004-2009). The 20-item Center for Epidemiologic Studies Depression Scale (CES-D) scale was used. Total fish consumption, n-3 highly unsaturated fatty acids (≥20C) (HUFA), n-3 polyunsaturated fatty acids (≥18 C)(PUFA), and plausible ratios (e.g. n-3 HUFAs:n-6 HUFAs) were estimated with two 24-hr dietary recalls. The prevalence of CES-D score ≥16 was 21.2% among men and 31.6% among women. In women, the uppermost tertile (T3) of fish consumption (compared to T1) was associated with reduced odds of CES-D score≥16 by 38%, with a significant effect modification by sex. The n-3 HUFA:n-6 PUFA ratio exhibited clear inverse dose-response relationship with elevated depressive symptoms among women [T2 vs. T1: OR = 0.68 (95% CI = 0.48, 0.98) and T3 vs. T1: OR = 0.59 (95% CI = 0.41, 0.86)]. For fish consumption, n-3 HUFA (% energy) and n-3 HUFA:n-6 PUFA ratio, a significant inverse relationship with the CES-D domain of somatic complaints and a direct relationship with positive affect was found only among women. In US women, increasing fish consumption, n-3 HUFA and the n-3 HUFA:n-6 PUFA ratio may decrease the risk of elevated depressive symptoms.
