HANDLS measures by wave

		Wave
Area	Measure	1	2	3	4	5	6	7

Biospecimen bank	Plasma			➂	➃	➄		➆
	Serum	➀		➂	➃	➄		➆
	DNA from blood	➀		➂	➃	➄		➆
	DNA from saliva			➂	➃	➄		➆^4.7
	Buccal mucosa	➀^5.1
	Saliva			➂	➃	➄		➆^6.7
	Urine			➂	➃	➄		➆
	Skin swab					➄		➆^8.7
	Toenail clippings					➄		➆^9.7

Clinical laboratory tests	Clinical blood tests	➀		➂	➃	➄	➅	➆
	COVID PCR test						➅	➆
	COVID rapid test						➅	➆
	COVID antibody test						➅	➆

Physical examination		➀		➂	➃	➄		➆

Ophthalmology	Refraction					➄		➆
	Fundus exam					➄		➆
	Optical Coherence Tomography							➆

Olfactory	Sniffin' Sticks					➄		➆^18.7

Medical history¹⁹		➀		➂	➃	➄		➆

Anthropometrics		➀		➂	➃	➄		➆

BMD & body composition (DXA)		➀		➂	➃	➄		➆

Cardiovascular assessment	ECG	➀		➂	➃	➄		➆
	IMT	➀			➃
	PWV	➀
	Echocardiogram			➂
	Endothelial function				➃
	Ankle brachial index				➃

Physical performance		➀		➂	➃	➄		➆

Physical functioning	ADL	➀		➂	➃	➄		➆
	IADL	➀		➂	➃	➄		➆
	Arthritis, joint pain	➀^31.1						➆^31.7

Nutrition	24h recall by AMPM	➀^32.1	➁^32.2	➂^32.3	➃^32.4
	OTC supplements			➂	➃

Cognition	Neuropsych tests	➀^34.1		➂^34.3	➃^34.4	➄^34.5		➆^34.7

Psychophysiology	Heart rate variability	➀^35.1

Health questionnaires	HRQoL	➀^36.1		➂^36.3	➃^36.4	➄		➆
	Dental care	➀		➂	➃
	Health-care services	➀		➂	➃	➄		➆
	Medical mistrust	➀
	Mental health services					➄		➆
	Headaches & migraines			➂	➃
	Sleep			➂	➃	➄		➆
	Implantable devices					➄

Personality	NEO-PIR		➁^44.2			➄^44.5	➅^44.6	➆^44.7
	Spirituality			➂	➃
	Big Five Inventory-10					➄		➆

Psychiatric screening	CES-D	➀^47.1		➂^47.3	➃^47.4	➄		➆
	PHQ-9				➃	➄		➆
	PDSQ	➀^49.1			➃^49.4	➄		➆
	PTSD symptoms	➀			➃	➄		➆
	Alcohol abuse	➀		➂	➃	➄		➆
	Physical or sexual abuse	➀		➂	➃	➄		➆

Physical activity	Physical activity	➀^53.1		➂^53.3	➃^53.4	➄^53.5		➆^53.7
	Accelerometery				➃^54.4

Health literacy				➂		➄		➆

Financial literacy				➂	➃

Household composition		➀		➂	➃	➄		➆

Neighborhood assessment		➀		➂	➃	➄		➆

Educational attainment		➀		➂

Employment		➀		➂	➃	➄		➆

Income & income supplements		➀		➂	➃	➄		➆

Psychosocial questionnaires	Anger	➀			➃
	Anger rumination				➃	➄		➆
	Banking & wealth				➃
	Caregiving			➂	➃
	Cigarette smoking & e-cigarettes				➃	➄		➆
	Coping	➀			➃	➄		➆
	Crime victimization					➄		➆
	Demands & criticism	➀				➄		➆
	Discrimination	➀			➃	➄		➆
	Emotional support	➀			➃	➄		➆
	Energy security					➄		➆
	Ethnic identity	➀			➃^73.4
	Exposure to childhood trauma				➃
	Financial strain			➂	➃	➄		➆
	Food security	➀			➃	➄		➆
	Foreclosure			➂	➃	➄		➆
	Gambling					➄		➆
	Gun safety					➄		➆
	Gun violence							➆
	Home safety					➄		➆
	Hostility				➃^82.4
	Internet use					➄		➆
	Interpersonal violence				➃
	John Henryism	➀
	Life orientation test				➃
	Life satisfaction					➄		➆
	Life purpose					➄		➆
	Loneliness				➃	➄		➆
	MacArthur social standing	➀		➂
	Memory complaints							➆
	Optimism				➃
	Pain				➃	➄		➆
	Perceived constraints on personal control					➄		➆
	Perceived mastery					➄		➆
	Perceived stress	➀			➃
	Religiousity	➀
	Risk-taking				➃
	Satisfaction with aging					➄		➆
	Satisfaction with domains of life				➃
	Satisfaction with local police					➄		➆
	Second-hand smoke exposure				➃	➄		➆
	Self-esteem				➃
	Sleepiness				➃
	Social support	➀			➃	➄		➆
	Stimulant drug use				➃
	Subjective Happiness Scale							➆
	Unfair treatment				➃
	Vigilance	➀				➄		➆
	Well-being				➃

^4.7COVID restricted some collection
^5.1Whatman filters
^6.7COVID restricted some collection
^8.7COVID restricted some collection
^9.7COVID restricted some collection
^18.7Scratch & sniff during COVID risk
¹⁹Cumulative history after 1st visit
^31.1WOMAC
^31.7WOMAC
^32.1In-person household & MRV interview
^32.2Single telephone interview
^32.3In-person MRV interview & telephone interview
^32.4In-person MRV interview & telephone interview
^34.1Benton Visual Retention Test, ETS Card Rotations, Identical Pictures, California Verbal Learning Test, Digit Span forward & backward, Animal fluency, Wide Range Achievement Test, Trails A & B, Clocks, Brief Test of Attention, Mini-Mental State Examination
^34.3Benton Visual Retention Test, ETS Card Rotations, Identical Pictures, California Verbal Learning Test, Digit Span forward & backward, Animal fluency, Wide Range Achievement Test, Trails A & B, Clocks, Brief Test of Attention, Mini-Mental State Examination
^34.4Short Portable Mental Status Questionnaire, Joggle
^34.5Short Portable Mental Status Questionnaire, Trails A & B
^34.7Short Portable Mental Status Questionnaire, Trails A & B
^35.11st 700 participants only
^36.1Health-related quality of life (SF-12)
^36.3Health-related quality of life (SF-12)
^36.4Health-related quality of life (SF-12 & CDC HRQOL-14 Healthy Days)
^44.2Telephone interview
^44.5Ancillary study
^44.6Ancillary study
^44.7Ancillary study
^47.1Interview by cognitive testers
^47.3Interview by cognitive testers
^47.4ACASI
^49.1Psychiatric Diagnostic Screening Questionnaire (OCD, Psychosis, Social phobia, Generalized anxiety scales)
^49.4Psychiatric Diagnostic Screening Questionnaire (Generalized anxiety scale)
^53.1NASA Johnson Space Center Physical Activity Scale administered to 1st 700 participants
^53.3NASA Johnson Space Center Physical Activity Scale
^53.4BAEKE
^53.5NHANES-III
^53.7NHANES-III
^54.4Ancillary study
^73.4Race consciousness
^82.4Buss-Perry Anger-Hostility short scales

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